Dr. Md. Masud Rana M. Pharm (RU), PhD (Japan)
Chairman and Associate Professor
PH
https://www.iu.ac.bd
About:
I am Dr. Md. Masud Rana, an Associate Professor of Pharmacy at Islamic University, Bangladesh, specializing in Natural Product Chemistry, Phytochemistry, synthetic chemistry, and Microbiology. Supported by the prestigious MEXT scholarship, I earned my Ph.D. in Biotechnology and Pharmaceutical Engineering from Toyama Prefectural University, Japan. My expertise covers total organic synthesis, natural product isolation, structure elucidation, medicinal chemistry, and molecular biotechnology, backed by hands-on proficiency in NMR, HPLC, LC-MS, GC-MS, and biological assays. My research focuses on cancer therapeutics, mechanistic oncology, total synthesis, overcoming antibiotic resistance, and Pharmaceutical Technology, and I am a registered A grade Pharmacist.
Research interest:
Isolation, Natural product chemistry, Total synthesis, Computer chemistry, Microbiology , Pharmacology, Pharmaceutical Technology
ResearchGate:
https://www.researchgate.net/profile/Md-Masud-Rana-40?ev=hdr_xprf
Google Scholar:
https://scholar.google.com/citations?user=XVbqCdsAAAAJ&hl=en
Publications
Isolation and In-vitro Antineoplastic Activities of Bioactive Metabolites Isolated from a Bacterium, DADA-1AIMR-24
International Journal of Research in Pharmacy and Biosciences
Bacteria are the most important source for the discovery of novel compounds. Bioactive metabolites obtaining from bacteria play a vital role to treat various infectious diseases and cancers. For this reason, the main objective of this study was to isolate and evaluate the anticancer activities of bioactive metabolites from a bacterium, DADA-1AIMR-24 against Ehrlich ascites carcinoma cell (EAC) using 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The bioactive metabolites were also tested for their anticancer activity against human head and neck cancer cell 93-VU-147T and TU686. The metabolites showed prominent cytotoxic activity in vitro against human head and neck cancer cell lines. The metabolites showed 100% of inhibition at the concentration of 62.5μg/ml against Ehrlich ascites carcinoma (EAC) cell. The results indicated that bioactive metabolites of DADA-1AIMR-24 have a good anticancer activity and could be useful to identify novel molecules with potential anticancer drugs for chemotherapeutic use.
2017-09-29
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In-vitro Assessment of Antimicrobial and Cytotoxic Activities of Crude Metabolites of DADA-1AIMR-24, a Bacterium Isolated from Soil in Bangladesh
Specialty Journal of Biological Sciences
The aim of this study was to screen antibacterial, antifungal and cytotoxic activities of crude metabolites of a bacterium DADA-1AIMR-24 isolated from soil in Rajshahi division, Bangladesh. The antibacterial activity of crude extracts was tested by agar well diffusion technique against Bacillus cereus, Staphylococcus aureus ATCC-259233, Listeria monocytogenes, Agrobacterium spp., Escherichia coli FPFC- 1407, Shigella dysenteriae AL-35587, Shigella sonnei and Shigella boydii. At the same time, antifungal activity was also conducted by disc diffusion method against Aspergillus niger, Tichoderma herzanium, and Microphomina phaseolina. The MIC values of the extract against Bacillus cereus, Staphylococcus aureus ATCC-259233, E. coli FPFC-1407, Shigella dysenteriae AL-35587, Shigella sonnei, Shigella boydii were 64, 64, 64, 64, 64 and 32 μg/ml respectively. The minimum bactericidal concentration (MBC) was also determined (Table 2). The MBC values of the extract were 128, 128, 128, 128, 128 and 64 μg/ml. As the MBC value was higher than the MIC value, it is clear that the extract was bacteriosatic not bactericidal. The approximate counts of bacteria in the MIC tubes were also determined (table 2). The brine shrimp lethality bioassay was conducted to determine the cytotoxic nature of crude extracts, which showed that the degree of lethality of extracts was directly proportional to the concentration (LC50 21.55 μg/ml) compounds in the crude extract but due to low production of metabolites, we could not extract sufficient amounts as it took long time to produce metabolites. Further work is necessary to isolate and characterize the active compounds.
2017-09-29
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Cladoic Acid, an Anti-Trypanosoma cruzi Polyketide from Cladosporium sp. TP-F2020.
Journal of Natural Products.
A new polyketide, cladoic acid, was isolated from a fungus of the genus Cladosporium. The structure of the highly oxygenated trans-decalin ring with an all-E triene side chain was elucidated by extensive spectroscopic analysis. The unique chair/twist-boat conformation of the trans-decalin core and the flexibility of the B-ring were demonstrated by computer-aided conformational analysis. Cladoic acid was active against Trypanosoma cruzi and inhibited the proliferation of amastigotes and epimastigotes with IC50 values of 27 and 46 μM, respectively, but it did not show any appreciable activity against P388 murine leukemia cells, bacteria, or fungi, indicating it is a potential candidate for drug development against Chagas disease.
2024-08-05
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Synthesis of farinomaleins and their antimicrobial activities.
Bioscience, Biotechnology, and Biochemistry
A single-step synthesis of farinomalein A, a naturally occurring maleimide, by the radical-mediated introduction of an isopropyl group to bromomaleic anhydride and one-pot maleimide formation with β-alanine is reported. Antimicrobial testing of natural and unnatural farinomaleins synthesized using this protocol demonstrates that farinomalein A and some unnatural analogs are active against Bacillus subtilis, and one unnatural analog is active against Escherichia coli. The possible inhibitory activity of bacterial membrane and/or cell wall functions of farinomalein A was indicated by cell morphological studies.
2025-08-20
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Synthesis of the Decalin Structure of Cladoic acid.
Bioscience, Biotechnology, and Biochemistry.
The intramolecular Diels-Alder reaction was employed for the assembly of the trans-decalin structure of cladoic acid, an anti-Trypanosoma cruzi active polyketide isolated from a fungus of the genus Cladosporium. Although the cycloaddition provided the desired trans-octalin as a minor product, the method was effective for simultaneously constructing four stereocenters in the B-ring of cladoic acid.
2025-10-27
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